TARDBP and amyotrophic lateral sclerosis: Transactive response (TAR) DNA‐binding protein 43 (TDP‐43) and fused in sarcoma (FUS) have also been genetically and pathologically linked to ALS; however, the underlying mechanisms by which these induce ALS pathology and the causal relationship between these events and the death of the motor neurons remain unclear (Mackenzie et al, 2010).