Transactive response (TAR) DNA‐binding protein 43 (TDP‐43) and fused in sarcoma (FUS) have also been genetically and pathologically linked to ALS; however, the underlying mechanisms by which these induce ALS pathology and the causal relationship between these events and the death of the motor neurons remain unclear (Mackenzie et al, 2010). Here, FUS is linked to amyotrophic lateral sclerosis.