Three cardiac apoptotic pathways, such as caspase‐8‐mediated death receptor pathway, cytochrome C‐mediated mitochondrial pathway, and ER caspase‐12‐initiated pathway, are involved in heart failure (Nakagawa et al, 2000; van Empel et al, 2005; McIlwain et al, 2013). This evidence concerns the gene CYCS and heart failure.