Nominal associations (p < 0.05) for SULT1A2 were found in both previous gene expression profiling [21] and DNA methylation profiling [42] studies; nominal results for only gene expression were observed for SULT1A1 and TUFM. Two genes in the Sherlock results, CYP2B7 (cytochrome P450 family 2 subfamily B member 7, pseudogene) and C19orf54 (chromosome 19 open reading frame 54), are located in another complex COPD locus on chromosome 19 [7]. The gene discussed is ACTMAP; the disease is chronic obstructive pulmonary disease.