PSEN1 and Alzheimer disease: The data suggested that the levels of BDNF and NGF significantly increased in the huMSCs-shNC group compared with the AD-Veh group, but the inhibition of autophagy in huMSCs could not promote the secretion of BDNF and NGF in the brains of APP/PS1 transgenic mice compared with that in the huMSCs-shNC group (Fig. 7e–h).