We selected a CKs cocktail able to mimic an inflammatory reaction that spreads in CNS containing IL-1β, well known determinant of neuropathy [3, 7], TNF-α, that is ubiquitary present during Th1/Th17 mediated inflammatory reactions, and GM-CSF, key cytokine responsible of pro-inflammatory effects in the CNS of MS animal models [29]. This evidence concerns the gene TNF and neuropathy.