To evaluate the effect of anti-tumor therapy on the functional capacity of the APC compartment, we established an in vitro system in order to analyze the expression of several maturation markers on DC derived in situ from monocytes [11] and on plasmacytoid and myeloid DCs present in PBMCs (cells CD123+ or CD11c + within Lin-1-/HLA-DR+ population respectively – Fig. 2a), after stimulation with a cocktail of pro-inflammatory cytokines [12]. The gene discussed is CD2BP2; the disease is neoplasm.