By studying the role of MDSCs in inhibiting immune surveillance of BC tumors, Verma et al., reported the increase of MDSCs from two different sources: monocyte-derived (cells CD11b + CD14+ CD124+ CD33+) and PMN-derived (cells CD11b + CD14- HLA-DR- CD66b + CD124+ CD15+) in peripheral blood of BC patients in neoadjuvant chemotherapy [34]. The gene discussed is IL4R; the disease is breast cancer.