In this regard, we speculate that the recovery of CD154 by Th1 cells may foster CD8 surveillance in BC patients treated with AC by promoting competent DCs after cognate CD40/CD40L interaction that probably stimulates IL-12 secretion as well as the up-regulation of adhesion and co-stimulatory molecules by DCs (e.g., CD83), all of which have been shown to occur after CD40 cross-linking on these two cell types [40–48]. This evidence concerns the gene CD40 and breast cancer.