An increased production of IL-12 was detected after tumor removal in the study by Della Bella et al. [20], this and that the clinical tumor response to A/C correlates with the production of IL-12 and CD83 expression by DCs in the present study suggest that the responsiveness of DCs to the pro-inflammatory stimuli used here is useful for monitoring the recovery of immune surveillance by DCs during neoadjuvant treatment with A/C. This evidence concerns the gene CD83 and neoplasm.