Genetic data of several separation-of-function p53 mutant mice suggest that there are additional p53 functions that contribute to tumor progression, which are transcription independent; Murine p53 R172P, corresponding to human R175P, retains much of its tumor suppression function despite loss of transcriptional induction and loss of apoptosis (Liu et al., 2004). Here, TP53 is linked to neoplasm.