This reduction in angiogenesis could be attributed to hyperglycemia-induced impairment of Akt activation (Vind et al., 2012) and defects in angiogenesis(Larger et al., 2004) caused by H19-related impairment of the insulin-PI3K-Akt pathway (Gao et al., 2014). Here, INS is linked to Hyperglycemia.