In glioma, LncRNA-H19 was upregulated in microvessels from glioma tissues and in glioma-associated endothelial cells (ECs) cultured in glioma-conditioned medium, while knockdown of LncRNA-H19 suppressed glioma-induced angiogenesis (Jia et al., 2016). This evidence concerns the gene H19 and central nervous system cancer.