It has been demonstrated that p-STAT3 activation is required to sustain EMT-associated phenotypes in ovarian and breast cancers.20,21 Moreover, p-STAT3 activation is associated with lung cancer.22 Our results support the potential role of p-STAT3 activation in promoting metastasis and EMT and inducing the formation of VM patterns in CRC. Here, STAT3 is linked to breast carcinoma.