For example, some affected individuals experience muscle spasm and weakness.83 Interestingly, many Wilson disease patients experience swallowing difficulty, which is dependent on skeletal muscle function, before developing other neurologic symptoms.84 The stable expression of ATP7B during myogenic differentiation, suggest that there is a basal requirement for ATp7B in both proliferating myoblasts and differentiated muscle cells, but future experiments are required to identify the key functions of ATP7B in muscle cells. This evidence concerns the gene ATP7B and Wilson disease.