A modified IFN score, a sum of three type I IFN-inducible gene expression levels (lymphocyte antigen 6 complex locus E (LY6E), 2′,5′-oligoadenylate synthetase-like (OASL), and IFNα-inducible protein (clone IFI-15K) (ISG15)) or the LY6E level alone has also served as reliable biomarkers in diagnosing SLE [4]. Here, IFNA1 is linked to systemic lupus erythematosus.