In mice, the absence or reduction of IFNγ, IL-12 and IL-2 correlated with increased lung and brain fungal burden, increased lung eosinophilia, reduced numbers of macrophages expressing inducible nitric oxide synthase, increased fungal dissemination to the brain and overall increased susceptibility to infection [40,42,44,115,116,117,118]. Here, IFNG is linked to infection.