Indeed, this learning paradigm has been tested in many transgenic mouse models of AD, including APP transgenic mice (Tg2576 mice) [15, 16], PS1/APP double-transgenic mice [17, 18], and 3xTg-AD mice, which harbor mutant genes for human APP, PS1, and tau [19, 20]. This evidence concerns the gene PSEN1 and Alzheimer disease.