First, we can determine if the associated variant, or another in strong LD with it, is a non-synonymous coding variant, using for example ANNOVAR.67 If we focus on the 28 published risk variants that had a reproducible association with asthma in the UK Biobank study (Table 2), and also include the additional correlated risk variants reported in other asthma GWAS (Supplementary Table 4), then this approach identifies eight likely target genes: GSDMA, GSDMB, HLA-DQA1, HLA-DQB1, IL1RL1, IL6R, TLR1 and ZPBP2 (Supplementary Table 6). This evidence concerns the gene TLR1 and asthma.