ADORA1 and asthma: For example, the asthma protective allele rs6683383:A is strongly associated with increased expression of ADORA1 in whole-blood (for example, beta=0.40, P=10−44130), suggesting that agonists and not antagonists (such as PBF-680, which is currently being tested in a phase 2 trial in asthma: NCT02635945) might be beneficial in asthma.