ACHE and poisoning: Because AChE is the main target of OPs, the principles of existing therapy of acute poisoning are converged to elimination of effects of AChE inhibition by OPs, that is, administration of cholinolytics (e.g., atropin), reactivators of AChE (oximes), and anticonvulsant drugs (agonists of GABA- and antagonists of glutamate receptors); as a preventive means before the alleged poisoning, reversible AChE inhibitors can be used (e.g., pyridostigmine) [193, 194].