MYH14 and colitis: Recently, Dhawan et al. showed that M-type cholinergic receptor (mAChR) also provides protective effects against colitis in in vitro experiments and that mAChR stimulation might block the phosphorylation of myosin light chain, inhibit myosin contraction, and thus maintain the tight junction protein in a close state and protect the epithelium barrier function [17, 18].