These studies have shown that CAFs transformed from MSCs express fibroblast-activated protein (FAP), α-smooth muscle actin (α-SMA), and stromal-derived factor 1 (SDF-1) and display enhanced proliferation and secretion of cytokines including IL-6 and TGF-β which could contribute to a tumor-supportive microenvironment. The gene discussed is IL6; the disease is neoplasm.