Zhang et al. [77–79] published several papers suggesting that the TNF2 allele (TNF-α −308A) is associated with death as a result of SAP-associated septic shock, but the polymorphism may not function because no significant differences were found in the serum levels of TNF-α. In spite of the critical role of TNF-α in AP, it can hardly be a marker because of the short half-life. Here, TNF is linked to alkaline phosphatase measurement.