Whilst the induction of p53 transactivation of cancer cells harboring R273H mutant p53 by natural bioactive compounds curcumin, flavokawain and alpinetin have been demonstrated elsewhere (Lim et al., 2007[24]; Lin et al., 2015[25]; Malami et al., 2017[27]; Song et al., 2005[31]; Ye et al., 2015[40]), the molecular mechanism involving restoration of wild-type p53 functional activity is still not understood. This evidence concerns the gene TP53 and cancer.