TP53 is a tumor-suppressor protein that prevents cancer development through transcriptional regulation of target genes implicated in mutagenic cells potential for neoplastic transformation, cell cycle progression, DNA repair, and apoptosis (Bensaad et al., 2006[2]; Haupt et al., 2003[14]; Moll et al., 2006[28]). The gene discussed is TP53; the disease is cancer.