TP53 and neoplasm: There are several limitations observed in this study, for instance, the fact that these bioactive compounds could induce p53 protein expression in tumor cells expressing R273H mutant p53 as previously reported elsewhere (Lim et al., 2007[24]; Lin et al., 2015[25]; Malami et al., 2017[27]; Song et al., 2005[31]; Ye et al., 2015[40]) does not prove these molecules to have rescued R273H mutant p53.