Third, LAIVs have been shown to stimulate more robust systemic humoral response (Cheng et al., 2013, De Villiers et al., 2009, Katsura et al., 2012, Nogales et al., 2016b, Rodriguez et al., 2017c, Victor et al., 2012) and elicit cellular immunity (Cheng et al., 2013, Katsura et al., 2012), leading to recruitment of influenza-specific CD8 T cells in the target tissues of the respiratory tract (Baker et al., 2013, Guo et al., 2014, Katsura et al., 2012, Nogales et al., 2016b, Powell et al., 2012, Rodriguez et al., 2017c, Uraki et al., 2013). This evidence concerns the gene CD8A and influenza.