These results clearly suggest that hyperglycaemia-induced EMT on fibronectin triggers a metabolic switch towards the Warburg effect with increased glucose uptake predominantly via the GLUT12 transporter, increased lactate production along with upregulation of enzymes and transporters for lactate (i.e., LDHA and MCT2 and MCT4), increased serine biosynthesis and a concurrent downregulation of TCA cycle activity. Here, FN1 is linked to Hyperglycemia.