A recent discovery that the 27-hydroxycholesterol biosynthetic pathway is involved in the regulation of resistance to estrogen deprivation in ERα-positive breast cancer cells [47] may be linked to the way in which caveolin-1 mediates the induction of invasion observed when we targeted the FASN/ERα pathway in an attempt to inhibit hyperglycaemia-induced, matrix-specific EMT in breast cancer epithelial cells. The gene discussed is CAV1; the disease is breast cancer.