With respect to the latter, we observed that hyperglycaemia-induced, matrix-specific EMT was associated with a significant increase in glucose uptake predominantly via the GLUT12 transporter, higher levels of lactate secretion along with upregulation of the LDHA enzyme and MCT2 and MCT4 lactate carriers and decreased dependency on oxidative phosphorylation (OXPHOS). This evidence concerns the gene LDHA and Hyperglycemia.