We initially focused our attention on the BAFF pathway, because it is the only TNFRSF pathway that depends chiefly on non-canonical NF-κB signaling37 and should therefore be fully inhibited by NIK SMI1, and also because the BAFF blocking antibody Belimumab is an FDA-approved drug for lupus, thus representing an ideal benchmark. Here, NFKB1 is linked to systemic lupus erythematosus.