The PARP1/2 imaging agent [18F]PARPi is therefore well suited to image in PARP1-expressing tumors, quickly clearing from non-target tissue while binding strongly to tumor over the course of 2 h resulting in a tumor/muscle ratio of 7.6 ± 2.7 in JHU-LX48 bearing animals (P = 0.0072; Fig. 4c). Here, PARP1 is linked to neoplasm.