This community-based prospective cohort study of older individuals with normal cognitive function revealed that cognitive decline was associated with a 6-year increase in insulin resistance, after adjusting for age, sex, baseline K-MMSE, education duration, baseline GDS-K, smoking status, history of diabetes, history of hypertension, BMI, and apolipoprotein E ε4 genotype status. This evidence concerns the gene APOE and hypertensive disorder.