RNF168 and urethra adenocarcinoma: In UAD, Leu429, Ile430, Leu432, and Leu436 of RNF168 form a hydrophobic surface to interact with the Ile36-centered hydrophobic patch of Ubdist, which comprises Ile36, Pro37, Leu71, Leu73 and the aliphatic portion of Thr9 (Fig. 3b, left).