To this aim, we screened an independent BCP-ALL cohort (n = 2 KMT2A-rearranged, n = 1 BCR-ABL1, n = 21 B-other, n = 17 ETV6-RUNX1, n = 21 high hyperdiploid) for DUX4-rearrangements and ERG deletions. Here, DUX4 is linked to acute lymphoblastic leukemia.