In conclusion, we identified shared genetic variation between SCZ and lung cancer in the CHRNA3/CHRNA5/CHRNB4 cluster on chromosome 15q25.1, and two other loci (6p22.1, 11q12.1) show cross-phenotype association and downstream pleiotropic effects on gene-expression in relevant tissue types for lung cancer and SCZ. Here, CHRNA5 is linked to lung carcinoma.