In the current study, we performed a systematic and comprehensive identification of dysregulated lncRNAs in CRC, and found four lncRNAs, CRCAL-1, CRCAL-2, CRCAL-3 and CRCAL-4, as novel lncRNAs involved in colorectal carcinogenesis. The gene discussed is LINC00858; the disease is colorectal carcinoma.