NLRP3 and myocardial infarction: Crucially, pharmacological inhibition of the NLRP3 inflammasome (using 16673-34-0) has been shown to reduce MI size in the murine heart, when administered at time of reperfusion, and even up to 60 min after the onset of reperfusion (Toldo et al., 2016), making it an attractive therapeutic target in STEMI patients treated by PPCI.