Interestingly, it has been recently shown in a large phase III Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) clinical trial (NCT01327846), that quarterly subcutaneous injections of ACZ885 (also known as canakinumab, a monoclonal antibody against IL-1β) in combination with standard of care prevented recurrent cardiovascular events (CV death, non-fatal MI, and non-fatal stroke) over a median follow-up of 3.8 year among 10,061 people with prior myocardial infarction and with a high-sensitivity C-reactive protein (hsCRP) level of ≥ 2 mg/L. The gene discussed is IL1B; the disease is stroke disorder.