CRK and cancer: The highly-interconnected relationships of the CCND1-CCND2-IGF1R-CRK-MYC sub-network predicts that these could participate in ceRNA-functional co-regulation, which would integrate insulin hormone signaling (IGF1R) with key cellular proliferation components (MYC, Cyclins D1 and D2, CRK), well-known for their association with cellular proliferation and cancer (Fig. 3c).