The Arf6 pathway appears to drive the epithelial-mesenchymal transition (EMT) of cancer cells; this pathway downregulates E-cadherin and upregulates integrin recycling and focal adhesion dynamics, when AMAP1 binds to PRKD2 and EPB41L5 [15, 17, 19, 20]. The gene discussed is ASAP1; the disease is cancer.