Apoptotic, necrotic/necroptotic, and autophagic cells within the tumor microenvironment release damage-associated molecular patterns (DAMPs) which represent mediators including S100 proteins, ATP, heat shock proteins, hyaluronan, HMGB1 (high mobility group box 1), and calcireticulin [53] and are sensed by pattern recognition receptors (PRRs) such as toll-like receptors [54]. This evidence concerns the gene HMGB1 and neoplasm.