It has been demonstrated that interleukin-1β (IL-1β) [8–10], interleukin-6 (IL-6) [9], interleukin-8 (IL-8), [11], tumor necrosis factor-alpha (TNF-α) [10, 12, 13], phospholipase A2 [9], nitric oxide synthase (NOS) [9], and cyclooxygenase-2 (COX-2) [14] are activated in the dorsal root ganglion (DRG) and/or the spinal cord in response to lumbar disc herniation and that their altered expression is closely related to radicular pain. The gene discussed is TNF; the disease is lumbar disc herniation.