DUX4 and facioscapulohumeral muscular dystrophy: In previous studies, we developed antisense oligomers (AOs) and siRNAs targeting DUX4 mRNA to suppress DUX4 protein expression as a therapeutic approach for FSHD, with a focus on the atrophic myotube phenotype observed in primary cultures [32], and found that DUX4 mRNA silencing did not correct the disorganized FSHD myotube phenotype [24].