In contrast to DUX4, which is only immunodetected in 1/1000 to 1/200 of FSHD myonuclei [16, 96], DUX4c is observed in almost all FSHD myoblasts [28], and the present study suggests that DUX4c could initiate muscle fiber disorganization, favor formation of large clusters of nuclei, and disturb regeneration, thereby providing a “weakened” background, facilitating DUX4 toxicity. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.