MGD009 is a humanized DART protein that binds both T cells and tumor-associated B7-H3 and is being studied in a phase I clinical study in patients with B7-H3 expressing tumors including melanoma, non-small cell lung carcinoma (NSCLC), mesothelioma, and urothelial cancers [14]. This evidence concerns the gene CD276 and non-small cell lung carcinoma.