CEA CD3 TCB (RG7802, RO6958688) is an IgG1 BiTE that simultaneously binds carcinoembryonic antigen (CEA) on tumor cells and CD3 on T cells to increase tumor-infiltrating lymphocytes (TIL) activation, infiltration, and expression of PD-1/PD-L1 [11]. The gene discussed is CD274; the disease is neoplasm.