Factors such as thrombospondin, urokinase-type plasminogen activator (uPA), epithelial growth factor (EGF), serpin E1, matrix metalloproteinases (MMPs) and dipeptidylpeptidase IV (CD 26) belong to the secretome of activated PSCs that promotes tumor invasion [37–39]. The gene discussed is SERPINE1; the disease is neoplasm.