The inflammatory response network contains several genes that have been previously associated with allergic disease, including Socs3, Il9r, Icam1, and Stat5b. Additionally, Etv5 is a transcription factor known to positively regulate Icam1 [31] and controls Th17 differentiation through the regulation of Il17a and Il17f expression [32]. This evidence concerns the gene SOCS3 and allergic disease.