Another latest study on nsSNPs and their effects on patients with non-small cell lung cancer treated with immunotherapy suggested that the combination of deleterious SNPs and known pathogenic lesions might help in getting advantage from immunotherapy [20].This study is aimed to investigate nsSNPs of T-cell Activation Rho GTPase Activating Protein (TAGAP) and their effects on its structure and function. Here, TAGAP is linked to non-small cell lung carcinoma.