A series of pyrazole derivatives bearing Sorafenib scaffold were synthesized by Wang et al. and evaluated for the cytotoxicity against A549, HepG2, MCF-7, and PC-3 cancer cell lines and some selected compounds were further evaluated for the activity against VEGFR-2/KDR, BRAF, CRAF, c-Met, EGFR and Flt-3 kinases. This evidence concerns the gene KDR and cancer.