Recent studies have shown that the kinases PLC-1 and DKF-1, the Caenorhabditis elegans orthologs of mammalian phospholipase C (PLC) and protein kinase D1 (PRKD1/PKD), respectively, are required for TFEB/TFE3 activation during bacterial pathogen infection [113] and, hence, establishing their additional involvement in the innate immune response and inflammation [113,114,115], which might impact cancer initiation and progression [116]. Here, PRKD1 is linked to cancer.