UCP1 and obesity due to melanocortin 4 receptor deficiency: This study suggests that the anti-obesity effect of fucoxanthin is mediated by alterations in the functioning of lipid-regulating enzymes that could raise plasma adipokine levels and promote higher expression levels of uncoupling protein 1 (UCP1) and β3-adrenergic receptor (Adrb3) in abdominal fat tissues (Figure 6A).