Insulin like growth factor-1 receptor (IGF-1R), Platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR), tyrosine-kinase receptor encoded by the KIT locus (KIT), and epidermal growth factor receptor (EGFR) were reported to be overexpressed or constitutive activated by gene deletion, amplification of rearrangement, in malignant glioma [2,3,4,5,6].One of the most popular treatments which was intensely trialed during this period for GBMs involved the Epithelial Growth Factor (EGF) and its’s receptor, the Epithelial Growth Factor Receptor (EGFR). The gene discussed is IGF1R; the disease is malignant glioma.