BRCA1 and neoplasm: There is currently an ongoing trial in patients with PDAC, that defines BRCAness as HR deficient but germline BRCA proficient (tumours with somatic BRCA mutation, Fanconi anemia gene, ATM or BRCA1/BRCA2-containing complex, subunit 5 (RAD51) mutations) and is investigating the efficacy of treating these patients with the PARP inhibitor olaparib [51].