We observed that while HG and hyperglycaemia induce the expression of pro‐fibrotic markers (collagen I, TGF‐β and CTGF) and cardiac hypertrophic markers (ANP, BNP and MyHC), 6b significantly attenuated the up‐regulation of these fibrotic and hypertrophic biomarkers. Here, NPPB is linked to Hyperglycemia.