We observed that while HG and hyperglycaemia induce the expression of pro‐fibrotic markers (collagen I, TGF‐β and CTGF) and cardiac hypertrophic markers (ANP, BNP and MyHC), 6b significantly attenuated the up‐regulation of these fibrotic and hypertrophic biomarkers. The gene discussed is TGFB1; the disease is Hyperglycemia.