RUNX1 and acute myeloid leukemia: AML with t(8;21)(q22;q22) or with inv(16)(p13;q22) or t(16)(p13;q22), which disrupt CBFB the non-DNA-binding partner of RUNX1, are included under the category of “AML with recurrent genetic abnormalities” in the 2016 WHO classification scheme (Arber et al., 2016) and together are often referred to as “core-binding factor acute myeloid leukemia” (CBF-AML).