Thus, RUNX1 mutations in sporadic AML are usually intermediate secondary events that drive disease progression (Jan et al., 2012; Corces-Zimmerman et al., 2014; Shlush et al., 2014; Hirsch et al., 2016; Papaemmanuil et al., 2016). The gene discussed is RUNX1; the disease is acute myeloid leukemia.