Strikingly, the French group found no mutations in CDC25C. A third group (Churpek et al.)from the United States analyzed somatic mutations in 7 FPD/AML patients with MDS or AML and found no mutations in either CDC25C or in the second RUNX1 allele, but instead, identified mutations in a collection of other genes including BCOR, PHF6, DNMT3A, TET2, CREBBP, U2AF1, NUP214, SMC3, and PDS5B (Churpek et al., 2015). The gene discussed is SMC3; the disease is acute myeloid leukemia.