In this mini-review, we report the tumor growth consequences of re-routing fermentative glycolysis by genetic disruption at three key levels studied in our lab: glucose-6-phosphate isomerase (GPI), lactate dehydrogenase (LDHA and B isoforms), and at the level of export of lactic acid [monocarboxylate transporter (MCT) isoforms]. The gene discussed is LDHA; the disease is neoplasm.