Steroids have potent anti-inflammatory effects; they inhibit the formation of both prostaglandins and leukotrienes, and decrease intracellular and extracellular edema by suppressing macrophage activity, reducing lymphokine production, downregulating the production of VEGF, and via their vasoconstrictive effect.13 After the SCORE study reported good short-term efficacy data on intravitreal triamcinolone acetonide both in terms of improving visual acuity and reducing central macular thickness (CMT) in patients with macular edema secondary to CRVO, observation was no longer an acceptable choice. This evidence concerns the gene VEGFA and macular retinal edema.