Furthermore, the classical anti-inflammatory effect of IL-10 could be denoted by the significant reduction in both pulmonary and systemic proinflammatory cytokines (IL-1b, IL-6, CXCL1, IL-17, and TNF-α) for the mice submitted to exercise (Exe and COPD+Exe groups). The gene discussed is IL1B; the disease is chronic obstructive pulmonary disease.