CSRP1 and atrial septal defect: Genotype-phenotype analysis across the extended pedigree did not support any role for CSRP1 in the polydactyly phenotype, but suggested a potential role in the cardiac phenotype observed in the core family since the third affected child with ASD III-12 carried the variant, whereas proband III-9 who has no cardiac phenotypes did not (Table 1).