So far, at least 50 human disease genes have been associated with CHD, however, a small set of developmental genes [for example, NKX2-5 (MIM# 600584), GATA4 (MIM# 600576) and NOTCH1] harbor the majority of these CHD-associated mutations (Fahed et al., 2013). Here, NOTCH1 is linked to coronary artery disorder.