Interestingly, in mice miR-21 has also been shown to induce tumor angiogenesis by targeting PTEN and activating AKT and ERK1/2 signaling pathways, which then in turn enhances VEGF and hypoxia-inducible factor 1-alpha (HIF1A) expression (Liu et al., 2011). Here, AKT1 is linked to neoplasm.